BioBucks

Upfront Briefing

Biotech came back from the long weekend to a policy hangover and a risk-off tape. XBI and the Nasdaq Biotechnology Index fell more than 2% as investors processed a vaccine-policy firestorm at FDA and fresh macro jitters.

On the policy front, controversial vaccine-safety claims from an ACIP chair and an FDA official are putting federal vaccine oversight under the microscope, while the House moved to keep rare pediatric priority review vouchers alive and the FDA itself leans into agentic AI to streamline its own work.

Commercially, the UK is agreeing to boost drug spending by 25% to dodge US tariffs, Lilly is trimming Zepbound self-pay prices again as GLP-1 competition bites, Novo Nordisk's semaglutide just missed in Alzheimer's, and dealmakers are still writing checks—from Regeneron’s gene editing tie-up with Tessera to a $130M Series B for amyloidosis and new capital plans in Alzheimer’s and Stargardt disease.

Market Moves

Instrument Last close 1D % YTD %
S&P 500 6812.63 -0.53% 15.83%
Nasdaq 100 25342.85 -0.36% 20.61%
Russell 2000 2469.13 -1.25% 10.72%
SPDR S&P Biotech 119.85 -2.69% 33.08%
Nasdaq Biotechnology Index 5691.96 -2.17% 32.04%
VIX 17.24 5.44% -0.63%
US 10Y 4.10% +7.9 bps n/a

Top 3 Headlines

1
FDA vaccine policy under scrutiny amid controversial claims

Controversial claims by a new ACIP chair and an FDA official regarding vaccine safety could impact public trust and future policy. Vaccine developers' stocks dipped after a memo on vaccine policy became public.

Why it matters: Controversial claims by a new ACIP chair and an FDA official regarding vaccine safety could impact public trust and future policy.

Source: Endpoints News

More: Endpoints News (analysis); STAT; BioCentury (policy); BioCentury (market)

2
UK boosts drug spending to avoid US pharma tariffs

The UK has agreed to increase drug spending by 25% to avoid US pharmaceutical tariffs. This decision could impact pharmaceutical pricing and market access.

Why it matters: The UK's agreement to increase drug spending to avoid US tariffs could impact pharmaceutical pricing and market access.

Source: BioSpace All News

More: BioPharma Dive; Endpoints News

3
Eli Lilly lowers Zepbound self-pay prices amid GLP-1 competition

Eli Lilly has again cut Zepbound's self-pay prices when purchased through its direct-to-consumer program. This reflects competitive pressures in the GLP-1 market.

Why it matters: Lilly's price cuts for Zepbound reflect competitive pressures in the GLP-1 market, potentially impacting sales and market share.

Source: BioSpace All News

More: Endpoints News

More Headlines

  • Vandria advances Alzheimer's drug VNA-318 to Phase 2 and is planning a Series B raise after first-in-human data. — Endpoints News
  • Belite Bio's Stargardt disease treatment succeeds in Phase 3, positioning the company to seek the first FDA approval for this rare eye condition. — Endpoints News
  • House passes a bill to reauthorize the rare pediatric priority review voucher program, sending it to the Senate next. — Endpoints News
  • Biotechs are securing alternative fill/finish capacity amid scrutiny of a Novo Nordisk site, underscoring supply chain and regulatory vulnerabilities. — BioSpace All News
  • Janux's prostate cancer immunotherapy shows a dropped response rate in new early-stage data, raising questions for future development. — Endpoints News
  • FDA adopts agentic AI as part of its push to integrate artificial intelligence into agency operations, aiming to streamline regulatory processes. — Fierce Biotech
  • Novo Nordisk's semaglutide misses its endpoints in an Alzheimer's trial, marking a setback for GLP-1 repurposing in neurodegenerative disease. — BioCentury

Deal Flow

M&A

  • Regeneron inks a $150M gene editing deal with startup Tessera focused on an AATD treatment, underscoring continued investment in genetic medicines for rare diseases. — BioPharma Dive

VC & Private Financings

  • Novartis-backed Protego raises $130M in Series B funding to advance a pivotal study in AL amyloidosis, a rare and serious disease. — BioSpace All News
  • Vandria is planning a Series B raise to move its Alzheimer's candidate VNA-318 into Phase 2 after first-in-human data. — Endpoints News

IPOs & Follow-Ons

  • No notable IPOs & follow-ons in the last 24 hours.

Academic Corner

  • Liraglutide in mild to moderate Alzheimer’s disease: a phase 2b clinical trial — Nature Medicine

Thanks for starting your day with BioBucks — we’ll keep sifting the noise so you can focus on the few moves that actually matter.

This content is for information only and is not investment or medical advice.

Keep reading

No posts found